Methodological Optimization of Catalytic Hydration of Alkynes with Mercury( II) p-Toluensulfonamidate Under Neutral Conditions
Angel M. Montana.
A systematic optimization study of reaction conditions of alkyne hydration, catalyzed by mercury(II) ptoluensulfonamidate
is described. Hydration takes place under catalytic conditions by using from 0.01 to 0.2 equivalents
of the easily available and inexpensive mercury(II) p-toluensulfonamidate in a hydroalcoholic solution, under mild and
neutral conditions. Different reaction parameters like temperature, concentration of substrates, equivalents of water and
catalyst, portionwise addition of the catalyst, thermal, microwave and ultrasound activation conditions and solvent type
have been studied and optimized.
Keywords: Acetylene hydration, mercury(II) p-toluensulfonamidate, catalyst, carbonyl formation
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