Current Stem Cell Research & Therapy

Anthony Atala  
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157
USA

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A Systematic Review of Tissue Engineered Meniscus and Replacement Strategies: Preclinical Models

Author(s): Behrooz Haddad, Behzad Haddad, Sujith Konan, Adetola Adesida, Wasim S. Khan.

Abstract:

Meniscal injuries are among the common sports injuries and their natural healing is limited. Removal of injured meniscus impairs normal knee function and predisposes patients to osteoarthritis. Tissue engineering and replacement strategies provide a novel approach for the treatment of severe meniscus injury. The aim of this article is to review preclinical studies that used approaches for meniscal replacement including growth factors, synthetic and tissue engineered scaffolds and non-meniscal autografts. Medline, EMBASE and UK PubMed search was performed and articles were assessed for inclusion. Included articles were summarised and categorised. Forty seven articles matched the inclusion criteria. The studies were classified according to the approaches used for meniscus replacement. Overall most experiments have shown good tissue integration and biochemical properties of the regenerated tissues. However, only few approaches have demonstrated satisfactory chondroprotective function.

Keywords: Meniscus, tissue engineering, systematic review, meniscal replacement, mesenchymal stem cells

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Article Details

VOLUME: 8
ISSUE: 3
Year: 2013
Page: [232 - 242]
Pages: 11
DOI: 10.2174/1574888X11308030008
Price: $58