Current Stem Cell Research & Therapy

Anthony Atala  
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157
USA

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Current Strategies of Tissue Engineering in Talus Chondral Defects

Author(s): Niccolo Martinelli, Carlo Bonifacini, Umile Giuseppe Longo, Andrea Marinozzi, Pino Florio, Wasim S. Khan, Vincenzo Denaro.

Abstract:

Due to the nature of articular cartilage of being poorly vascularized the capabilities of self repair are limited. Mesenchymal stem cells transplantation is a modern technique which has been developed after the high success rates obtained by microfracturing and drilling techniques which promote the release of growth factors and the infiltration of bone marrow derived cells in the lesion. In order to increase the concentration of bone marrow derived cells appropriate devices, the scaffolds, are necessary. These three dimensional constructs mimic the physiological ambient of chondrogenesis. The race for new scaffold materials, which will show high biocompatibility to prevent inflammatory response, high cellular adhesion properties with three dimensional architecture, high bioactivity to deliver growth factor appropriately and possibly high biodegrability has just begun. New studies will concentrate on the role, on the interaction and on the temporal sequence of growth factors to improve ostheocondral differentiation, but the necessity to increase the number of clinical studies with more patients and longer follow ups seems mandatory. The aim of this review is to update and summarise the evidence-based knowledge of treatment of talus chondral defect with new tissue engineering techniques.

Keywords: Bone marrow aspirate, mesenchymal stem cells, osteochondral lesions of the talus, scaffolds, tissue engineering

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Article Details

VOLUME: 8
ISSUE: 3
Year: 2013
Page: [217 - 221]
Pages: 5
DOI: 10.2174/1574888X11308030006
Price: $58