Cytochrome P450 2C19 Polymorphism and Antiplatelet Therapy. Who Should Really be Genotyped?

Author(s): George Kassimis, Eleana F. Stavrou, Dimitrios Alexopoulos, Aglaia Athanassiadou.

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 13 , 2013

Abstract:

CYP2C19 is one of the principal enzymes involved in the metabolism of clopidogrel. The genes encoding CYP enzymes are polymorphic, with common alleles conferring reduced function. A loss-of-function allele, CYP2C19*2, is associated with an increased risk of major adverse cardiovascular events, particularly stent thrombosis, in patients with acute coronary syndromes who are receiving clopidogrel, especially among those undergoing percutaneous coronary intervention. Newer, more potent P2Y12 inhibitors like prasugrel and ticagrelor have been introduced recently in the daily clinical practice with better cardiovascular outcome in these patients. The purpose of this review article is to provide information regarding the clinical use of CYP2C19 genotyping in patients requiring antiplatelet therapy.

Keywords: Clopidogrel, prasugrel, ticagrelor, percutaneous coronary intervention, CYP2C19 polymorphism, enzymes, metabolism, clinical practice, genotyping, cardiovascular events

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Article Details

VOLUME: 19
ISSUE: 13
Year: 2013
Page: [2489 - 2495]
Pages: 7
DOI: 10.2174/1381612811319130017
Price: $58

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