Mesenchymal stem cells (MSCs) were first isolated more than 50 years ago from the bone marrow. Currently MSCs may also
be isolated from several alternative sources and they have been used in more than a hundred clinical trials worldwide to treat a wide variety
of diseases. The MSCs mechanism of action is undefined and currently under investigation. For in vivo purposes MSCs must be produced
in compliance with good manufacturing practices and this has stimulated research on MSCs characterization and safety. The objective
of this review is to describe recent developments regarding MSCs properties, physiological effects, delivery, clinical applications and
possible side effects.
Keywords: Mesenchymal stem/stromal cells, cell therapy, graft versus host disease, immunomodulatory properties, regenerative medicine, advanced therapy medicinal product, transplantation, MSCs sources, clinical trials, clinical applications
Rights & PermissionsPrintExport