Effect of Aging on Metabolic Pathways in Endothelial Progenitor Cells

Author(s): Francesca Felice, Maria Chiara Barsotti, Pavel Poredos, Alberto Balbarini, Rossella Di Stefano.

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 13 , 2013


Abstract:

Age represents a significant risk factor for the onset and progression of cardiovascular disease, with the increase in life expectancy in developed countries going in parallel with increased incidence of such pathologies. Treatment strategies alternative or additive to pharmacological treatments are needed. The relationship between aging and progenitor cell-mediated repair is of great interest. Endothelial progenitor cells (EPC) mediate repair mechanisms for endothelial regeneration and maintenance, but they are subject to ageassociated changes affecting negatively their number and/or function.

Aim of this review is to examine the impact of age on EPC-mediated vascular repair, with a focus on the metabolic pathways involved and on the therapeutic targets with potential for attenuating this effect.

Keywords: Aging, senescence, vascular disease, endothelial progenitor cells, metabolic pathways, repair mechanisms, vascular repair, endothelial regeneration, pathologies, therapeutic targets

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Article Details

VOLUME: 19
ISSUE: 13
Year: 2013
Page: [2351 - 2365]
Pages: 15
DOI: 10.2174/1381612811319130003
Price: $65

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