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Mini-Reviews in Medicinal Chemistry
ISSN (Print): 1389-5575
ISSN (Online): 1875-5607
Epub Full Text Article
DOI: 10.2174/13895575113139990058      Price:  $95









Structure and Thermodynamics of Drug-RNA Aptamer Interactions

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Author(s): J.B. Da Costa and T. Dieckmann
Abstract:
This mini-review will provide an overview on the recent studies of structure and thermodynamics of RNA aptamers that target drug molecules. These aptamers are studied to provide insight into RNA drug interactions. This interaction is important due to the many roles RNA plays in cell biology.
Keywords:
Ribonucleic acid, aptamer, thermodynamics, isothermal titration calorimetry, RNA structure
Affiliation:
University of Waterloo, Department of Chemistry, 200 University Ave West, Waterloo, ON, Canada