Abstract
Midkine (MK) is a member of midkine family which is composed of MK and pleotrophin (PTN). MK behaves like a cytokine and growth factor, promotes the proliferation, differentiation, survival, adhesion, migration of cells. MK expression usually increases during ischemia, inflammation, tissue repair, neoplastic transformation and in different toxic conditions. Immune cells and most of organs have MK secretion function in fetal and adult life. MK could be a promising prognostic/diagnostic marker and a potential target in many of diseases including malignancy, toxic and inflammatory diseases. This review focuses on both cell protective and immune-modulatory roles of MK in different in vitro and in vivo disease models and human reports. MK is still a novel molecule in the regulation of organ development and the etiology of many diseases.
Keywords: Cytokine, immune system, inflammatory diseases, midkine, toxicity
Current Drug Delivery
Title:Midkine in Inflammatory and Toxic Conditions
Volume: 10 Issue: 1
Author(s): Nuray Yazihan
Affiliation:
Keywords: Cytokine, immune system, inflammatory diseases, midkine, toxicity
Abstract: Midkine (MK) is a member of midkine family which is composed of MK and pleotrophin (PTN). MK behaves like a cytokine and growth factor, promotes the proliferation, differentiation, survival, adhesion, migration of cells. MK expression usually increases during ischemia, inflammation, tissue repair, neoplastic transformation and in different toxic conditions. Immune cells and most of organs have MK secretion function in fetal and adult life. MK could be a promising prognostic/diagnostic marker and a potential target in many of diseases including malignancy, toxic and inflammatory diseases. This review focuses on both cell protective and immune-modulatory roles of MK in different in vitro and in vivo disease models and human reports. MK is still a novel molecule in the regulation of organ development and the etiology of many diseases.
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Cite this article as:
Yazihan Nuray, Midkine in Inflammatory and Toxic Conditions, Current Drug Delivery 2013; 10 (1) . https://dx.doi.org/10.2174/1567201811310010009
DOI https://dx.doi.org/10.2174/1567201811310010009 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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