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Immobilized Using Nanotechnology of Electron-Beam Synthesis Regulators of Progenitor Cells Functions: Remedies of New Generation for Regenerative Medicine

Author(s): Alexandr M. Dygai, Gleb N. Zyuz‘kov, Vadim V. Zhdanov, Vladimir V. Udut, Andrey V. Artamonov, Andrey A. Bekarev, Maria Y. Minakova.

Abstract:

Nanotechnological modifiers of progenitor cells functions - immobilized (im) granulocyte colony stimulating factor (G-CSF) and hyaluronidase (HD) have been created with the help of ionization radiation. The drugs’ effect on the function of progenitor cells of different classes and regenerative activity of these substances have been described. Hepatoprotective, cerebroprotective and hemostimulating effects of imG-CSF and hepatoprotective and hemostimulating properties of imHD have been demonstrated in the experiment. It has been established that the regenerative effect of imG-CSF on the blood system is connected with its influence on the hematopoietic precursors of hematopoietic tissue, and therapeutic effects under chronic hepatitis and hypoxic encephalopathy are determined by the mobilization and migration of multipotent progenitor cells of bone marrow in the target-organ. The stimulation of regional stem cells (SC) of affected tissues can be considered mechanisms of regenerative action of imHD. In addition, the mobilization and homing of bone marrow SC in the liver have the significant importance in realizing imHD therapeutic effects for chronic hepatitis. The drugs’ effects are determined by modification of the state of the tissue extracellular matrix, changes in the functioning of microenvironment cells and properties of the progenitor cells themselves. The relevant patents are discussed.

Keywords: Immobilized granulocyte colony stimulating factor, immobilized hyaluronidase, nanotechnology of electron-beam synthesis, progenitor cells, regenerative medicine, stem cells, CELL THERAPY, IMMOBILIZED G-CSF, Hemostimulating Activity, Hepatoprotective Activity

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Article Details

VOLUME: 3
ISSUE: 2
Year: 2013
Page: [160 - 175]
Pages: 16
DOI: 10.2174/2210296511303020006
Price: $100