Activity and Structure Elucidation of Ceramides
E. S. Elkhayat,
G. A. Mohamed,
S. R. M. Ibrahim.
Ceramide, a derivative of sphingolipid breakdown products, acts as second messenger for multiple extracellular
stimuli including growth factors, chemical agents, and environmental stresses. They have been shown to be crtically involved
in various biological processes, including differentiation, senescence, cell-cycle arrest, proliferation, and apoptosis.
Ceramide molecules form distinct domains in the cell membrane, which may serve to re-organize cellular receptors and
signaling molecules. Because of their promising biological activities and applications, here we focus on: biosynthesis, existence,
importance, and structure elucidation, as well as representative examples concerning their structure and activity.
Keywords: Ceramide, sphingolipid, biological activity, identification, breakdown products, multiple extracellular
stimuli, Hydrolysis, microbial pathogenesis, emporal organization, mitochondrial transmembrane potential
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