Current Bioactive Compounds

Adriano Mollica
Department of Pharmacy, University ”G. d' Annunzio” of Chieti-Pescara
Via dei Vestini 31
Chieti, 66100


Activity and Structure Elucidation of Ceramides

Author(s): E. S. Elkhayat, G. A. Mohamed, S. R. M. Ibrahim.


Ceramide, a derivative of sphingolipid breakdown products, acts as second messenger for multiple extracellular stimuli including growth factors, chemical agents, and environmental stresses. They have been shown to be crtically involved in various biological processes, including differentiation, senescence, cell-cycle arrest, proliferation, and apoptosis. Ceramide molecules form distinct domains in the cell membrane, which may serve to re-organize cellular receptors and signaling molecules. Because of their promising biological activities and applications, here we focus on: biosynthesis, existence, importance, and structure elucidation, as well as representative examples concerning their structure and activity.

Keywords: Ceramide, sphingolipid, biological activity, identification, breakdown products, multiple extracellular stimuli, Hydrolysis, microbial pathogenesis, emporal organization, mitochondrial transmembrane potential

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Article Details

Year: 2012
Page: [370 - 409]
Pages: 40
DOI: 10.2174/1573407211208040006
Price: $58