Antimicrobial Potential of Benzamides and Derived Nanosystems for Controlling in vitro Biofilm Development on Medical Devices

Author(s): Carmen Limban, Alexandru Mihai Grumezescu, Mariana Chirea, Lilia Matei, Mariana Carmen Chifiriuc.

Journal Name: Current Organic Chemistry

Volume 17 , Issue 2 , 2013

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Abstract:

The aim of this paper is to review the antimicrobial activity of thiourea derivatives against planktonic and adherent bacterial and fungal strains, as well as to show how nanotechnology could improve the intrinsic antimicrobial activity of the novel substances, by obtaining biocompatible nanocomposites based on magnetite nanoparticles and newly synthesized 2-((4-ethylphenoxy)methyl)-N- (alkylphenylcarbamothioyl) benzamides, which proved increased resistance to microbial colonization or inhibited the development of already existent biofilms, revealing a great potential for biomedical applications.

Keywords: Benzamides, Thiourea derivatives, Magnetic nanoparticles, Anti-biofilm properties, Quorum sensing inhibitors

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Article Details

VOLUME: 17
ISSUE: 2
Year: 2013
Page: [162 - 175]
Pages: 14
DOI: 10.2174/1385272811317020013
Price: $58

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