Wound Dressing Based Collagen Biomaterials Containing Usnic Acid as Quorum Sensing Inhibitor Agent: Synthesis, Characterization and Bioevaluation

Author(s): Alexandru Mihai Grumezescu, Ecaterina Andronescu, Madalina Georgiana Albu, Anton Ficai, Coralia Bleotu, Denisa Dragu, Veronica Lazar.

Journal Name: Current Organic Chemistry

Volume 17 , Issue 2 , 2013

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Abstract:

The aims of this research were to obtain improved wound dressings based on collagen (COLL), polysaccharides (dextran= DEX, diethylaminoethyl-cellulose= DEAEC), silica network and usnic acid, as quorum sensing inhibitor. FT-IR, SEM, interaction with eukaryotic cells and a novel protocol to evaluate the antimicrobial activity of the new wound dressing, firstly reported in literature were used for the characterization of fabricated wound dressings. The obtained wound dressings are not cytotoxic, do not influences the mesenchymal stem and exhibit good anti-biofilm properties. Taken together, these results are suggesting that the new systems can be safely used for local applications on the lesional tissues.

Keywords: Collagen biomaterial, Wound dressing, Usnic acid, Anti-biofilm

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Article Details

VOLUME: 17
ISSUE: 2
Year: 2013
Page: [125 - 131]
Pages: 7
DOI: 10.2174/1385272811317020007
Price: $58

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