The aims of this research were to obtain improved wound dressings based on collagen (COLL), polysaccharides (dextran=
DEX, diethylaminoethyl-cellulose= DEAEC), silica network and usnic acid, as quorum sensing inhibitor. FT-IR, SEM, interaction with
eukaryotic cells and a novel protocol to evaluate the antimicrobial activity of the new wound dressing, firstly reported in literature were
used for the characterization of fabricated wound dressings. The obtained wound dressings are not cytotoxic, do not influences the mesenchymal
stem and exhibit good anti-biofilm properties. Taken together, these results are suggesting that the new systems can be safely
used for local applications on the lesional tissues.