Transcranial Magnetic Stimulation in Schizophrenia: The Contribution of Neuroimaging

Author(s): Zhong-de Du, R. Wang, Ravi Prakash, S. Chaudhury, G. Dayananda.

Journal Name: Current Topics in Medicinal Chemistry

Volume 12 , Issue 21 , 2012

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Abstract:

At the most basic level, the Transcranial Magnetic Stimulation(TMS) is a neuro-scientific tool that exerts its action by influencing the neo-cortical functions. However, in-spite of so many well-evidenced roles of TMS in neuropsychiatric conditions, its exact mechanism of action remains to be known. More intriguing are its therapeutic effects in Schizophrenia at the Cerebral-level. In this review, we adopt a neuro-imaging approach for this exploration. We review the present literature for the studies in Schizophrenia which have used a combination of rTMS with 1) Electroenchephalogram (EEG) 2)The functional Magnetic Resonance Imaging (fMRI) and the 3) Positron Emission Tomography (PET)/ Single-Photon Emission Computed Tomography. The TMS-EEG combination provides direct effects of TMS on the electro- magnetic field (EMF) of brain. The TMS-fMRI/PET/SPECT combinations are very effective in exploring the functional connectivity in brains of Schizophrenia patients as well as in performing rTMS guided neuro-navigation. Our review suggests that TMS combined with other neuroimaging modalities are needed for a better clarification of its neural actions.

Keywords: Repetitive Transcranial Magnetic Stimulation (rTMS), Schizophrenia, mechanism of action, Electroenchephalogram (EEG), Functional neuro-imaging.

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Article Details

VOLUME: 12
ISSUE: 21
Year: 2012
Page: [2452 - 2457]
Pages: 6
DOI: 10.2174/1568026611212210015
Price: $58

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