Inosine monophosphate dehydrogenase (IMPDH), an NAD-dependent enzyme that controls de novo synthesis
of guanine nucleotides, has received considerable interest in recent years as an important target enzyme, not only for the
discovery of anticancer drugs, but also for antiviral, antiparasitic, and immunosuppressive chemotherapy. The field of
IMPDH inhibitor research is highly important for providing potential therapeutics against a validated target for disease intervention.
This patent review examines the chemical structures and biological activities of recently reported IMPDH inhibitors.
Patent databases SciFinder and Espacenet and Delphion were used to locate patent applications that were published
between January 2002 and July 2012, claiming chemical structures for use as IMPDH inhibitors. From 2002 to
2012, around 47 primary patent applications have claimed IMPDH inhibitors, which we analyzed by target and applicant.
The level of newly published patent applications covering IMPDH inhibitors remains high and a diverse range of scaffolds
has been claimed.
Keywords: Anticancer, antiviral, chemotherapy, immunosuppression, IMP-deydrogenase, IMPDH, inhibitor design
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