Pregnancy Associated Brucellosis
Jaffar A. Al-Tawfiq and Ziad A Memish
Affiliation: Ministry of Health, P.O. Box 54146, Riyadh 11514, KSA.
Keywords: Abortion, brucellosis, pregnancy, therapy, Erythritol, neonatal brucellosis, gravidas, bacteremia, rifampicin, interferonogens
Brucellosis is a zoonotic infection caused by Brucella spp. In endemic countries, the disease does not spare the
pregnant. There is evidence that brucellosis can induce abortion in humans. Positive cultures of brucella from human placenta,
aborted fetuses, and other products of conception were reported previously. It is speculated that brucellosis causes
fewer spontaneous abortions in humans than animals due to the absence of Erythritol in the human placenta and fetus. In
addition, the presence of anti-brucella activity in human amniotic fluid may also play a role. Rifampin is considered the
mainstay of treatment of brucellosis during pregnancy, in various combinations. In a retrospective study of brucellosis in
pregnancy, antepartum treatment with antimicrobial agents was more protective against the occurrence of abortion than no
or inadequate treatment. It seems that the incidence of abortion is not different among patients treated with either
trimethoprim-sulfamethoxazole with or without rifampicin. With therapy during pregnancy, the overall success rate resulting
in normal delivery is 90%. The article discussed few of the patents associated with brucellosis.
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