Xenobiotic Sulphation and its Variability During Inflammation: a Factor in Adverse Drug Reactions?

Author(s): R.H. Waring, R.M. Harris, J.O. Hunter, S.C. Mitchell.

Journal Name: Current Drug Metabolism

Volume 14 , Issue 3 , 2013

Become EABM
Become Reviewer

Abstract:

The interactions between disease processes and the metabolism of therapeutic drugs have not been systematically investigated. Inflammation, with the presence of pro-inflammatory cytokines, affects Phase 1 metabolism, particularly the activity of the CYP isoforms. Inflammatory factors also alter the activity of some Phase 2 enzymes, particularly the sulphotransferases (SULT isoforms) responsible for drug sulphonation and the enzyme pathway involved in the supply of sulphate for this reaction. Being ill may, therefore, in itself make drug metabolism unpredictable.

Keywords: Inflammation, Illness, Sulphation, Drug Metabolism, Xenobiotic, Drug Reactions, SULT, Isoforms, Phase 2, Cytokines, Sulphate

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 14
ISSUE: 3
Year: 2013
Page: [361 - 365]
Pages: 5
DOI: 10.2174/1389200211314030011
Price: $58

Article Metrics

PDF: 5