New Informatics and Automated Infrastructure to Accelerate New Leads Discovery by High Throughput Screening (HTS)

Author(s): Preston S. Donover , Marlin Yohn , Matthew Sim , Andrew Wright , Sandesh Gowda , Chip Allee , Amanda R. Schabdach , Melvin Reichman .

Journal Name: Combinatorial Chemistry & High Throughput Screening

Volume 16 , Issue 3 , 2013

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The Lankenau Institute for Medical Research Chemical Genomics Center, Inc. has developed a new (patents issued and pending) Nanotube Automated Repository System (NARS) for dynamic storage of millions of ‘single-shot’ samples stored in a new monolithic microtiter-storage tube plate of our own design we call ‘nanotubes.’ We have integrated the NARS with customized software to efficiently access up to 10,000,000 samples stored continuously frozen (–20°C) in a dehumidified enclosure and sealed in a new microtiter NARS plate that is SBS compliant. Additional software was developed to analyze HTS data from orthogonally pooled compound libraries. Following ‘de-convolution’ of pooled HTS data, the software designates confirmatory retest samples to be ‘cherry-picked’ using the NARS. The application of a new, fully-integrated infrastructure for new leads discovery is described in detail. Other applications for our technologies and new infrastructure are discussed.

Keywords: Automated sample retrieval system (ASRS), bio-repository, drug discovery, HTS, orthogonal pooling, sample management, sample store

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Article Details

Year: 2013
Page: [180 - 188]
Pages: 9
DOI: 10.2174/1386207311316030003
Price: $58

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