Licensed DNA Vaccines against Infectious Hematopoietic Necrosis Virus (IHNV)
Marta Alonso and Jo-Ann C. Leong
Affiliation: Department of Animal Health, Basque Institute for Agricultural Research and Development, Neiker-Tecnalia, Technological Park of Bizkaia, Berreaga 1, Derio, Bizkaia, Spain 48160.
This article reviews some of the recent patents on DNA vaccines against fish viruses, in particular against the
novirhabdovirus infectious hematopoitic necrosis virus (IHNV). Although very effective in protecting fish against IHNV,
only one DNA vaccine has been approved to date for use in Canada. In Europe and in US, its commercialization is restricted
due to safety concerns.
Keywords: Apoptosis, DNA vaccines, fish promoters, infectious hematopoietic necrosis virus, salmonid fish, suicidal DNA
vaccines, DNA-plasmid solution, aquaculture, coding sequences, fusion protein, shellfish pathogens, programmed cell death
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