A single pill daily fixed dose combination of Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate
(EFV/FTC/TDF) provides a potent and convenient treatment option for HIV/AIDS. The components have been shown to
be well tolerated and are effective in randomized controlled trials. A literature search revealed no case of hepatic failure
reported with this drug combination. We here in describe the 1st case of acute hepatic failure developing after 3 months of
treatment with EFV/FTC/TDF in a 41 year old African American male without pre-existing liver disease or risk factors.
Keywords: Drug induced hepatic failure, AIDS combination therapy, antiretroviral, NNRTI, Emtricitabine, hepatic failure, hepatotoxicity, gonococcal, syphilis, genital herpes
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