Deciphering Supportive Treatment Strategies for Toxic Epidermal Necrolysis

Author(s): Serge Jennes, Gerald E. Pierard, Philippe Paquet.

Journal Name: Current Drug Safety

Volume 7 , Issue 5 , 2012

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Abstract:

Toxic epidermal necrolysis (TEN) is a dreadful life-threatening syndrome typically induced by an adverse drug reaction. This condition is characterized by the sudden and extensive destruction of the epidermis. The patient should be promptly addressed to a burn unit where three types of treatment should be administered, namely, (a) specific topical care of the bullous/eroded skin areas, (b) systemic anti-apoptotic/necrotic treatments, and (c) supportive care preventing secondary internal organ failures. This latter aspect is covered by the present review and focuses on (a) early withdrawal of the causative drug, (b) airway management, (c) hydro-electrolytic control, (d) nutritional support, (e) antibiotherapy, (f) prevention of venous thrombosis and gastroduodenal ulcers, and (g) analgesia and anesthesia.

Keywords: Drug reaction, toxic epidermal necrolysis, burn, epidermis, bullous, apoptotic, necrotic, eroded, causative, antibiotherapy

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Article Details

VOLUME: 7
ISSUE: 5
Year: 2012
Page: [361 - 366]
Pages: 6
DOI: 10.2174/1574886311207050006
Price: $58

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