New Player on An Old Field; the Keap1/Nrf2 Pathway as a Target for Treatment of Type 2 Diabetes and Metabolic Syndrome
Dionysios V. Chartoumpekis and Thomas W. Kensler
Pages 137-145 (9)
Nuclear erythroid factor 2 like 2 (Nrf2) has been described as a transcription factor that serves as a master regulator
of the adaptive response to exogenous and endogenous oxidative and electrophilic stresses. Evidence of Nrf2 crosstalk
with other molecular pathways is increasing; recent publications have proposed a role of Nrf2 in the development of
obesity and in the highly regulated process of adipocyte differentiation through its interaction with other transcription factors
and receptors implicated in metabolic regulation. In the present review, we discuss the available data on the possible
role of Nrf2 in obesity and metabolic syndrome and the feasibility of using Nrf2 as a therapeutic target in the clinical
Diabetes, Keap1, Metabolism, Nrf2, obesity, Oxidative stress, endogenous, exogenous, Body Mass Index, sulfonylureas.
Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh. 200 Lothrop St., E1352, Thomas Starzl Bioscience Tower, Pittsburgh, PA, 15261, USA.