Transient receptor potential channels, especially the members of the melastatin family (TRPM), participate in
insulin secretion. Some of them are substrates for protein kinases, which are involved in several neurotransmitter, incretin
and hormonal signaling cascades in β cells. The functional relationships between protein kinases and TRPM channels in
systems of heterologous expression and native tissues rise issues about novel regulation pathways of pancreatic β-cell excitability.
The aim of the present work is to review the evidences about phosphorylation of TRPM channels in β cells and
to discuss the perspectives on insulin secretion.
Keywords: Pancreatic beta cells, Insulin, Phosphorylation, TRP channels, Insulin Secretion, Phosphorylation, GLUT, 2-adrenergic, Alzheimer disease , glucose-conditioned closure.
Rights & PermissionsPrintExport