the present review focuses on the synthesis and biological evaluation of polycyclic 4(3H)-quinazolinones containing fused
aromatic or heteroaromatic rings. The first part of the review is related to compounds with ring fused to the pyrimidine part of the quinazoline
core. Most of the quinazolinone alkaloids belong to this class of molecules. The second part presents molecules bearing extra
ring(s) fused to the benzo moiety of the quinazolinone skeleton. Their structural diversity opens new fields in the search of active molecules.
Keywords: Quinazoline, quinazolinone, nitrogen heterocycles, antitumor agents, antiviral
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