Abstract
Extracts of Scutellaria species have been used in Eastern traditional medicine as well in the Americas for the treatment of several human ailments, including cancer. Crude extracts or flavonoids derived from Scutellaria have been scientifically studied for potential anti-cancer activity using in vitro as well as animal models of various cancers, including breast cancer, prostate cancer, ovarian cancer and malignant gliomas. Phase I clinical studies have also been conducted to study the toxicity/efficacy of Scutellaria extract in patients with metastatic breast cancer. This article is a succinct review of pertinent research articles on the anti-tumor efficacy and associated molecular mechanisms of Scutellaria extracts, particularly those containing the flavonoid wogonin. The potential significance of Scutellaria flavonoids as an adjuvant therapy for malignant tumors is discussed.
Keywords: Scutellaria, flavonoid, wogonin, cancer, GSK-3, NF-κB, p38 MAPK.
Current Cancer Therapy Reviews
Title:Anti-cancer Scopes and Associated Mechanisms of Scutellaria Extract and Flavonoid Wogonin
Volume: 9 Issue: 1
Author(s): Paras S. Patel, Nirmal Joshee, Agnes M. Rimando and Prahlad Parajuli
Affiliation:
Keywords: Scutellaria, flavonoid, wogonin, cancer, GSK-3, NF-κB, p38 MAPK.
Abstract: Extracts of Scutellaria species have been used in Eastern traditional medicine as well in the Americas for the treatment of several human ailments, including cancer. Crude extracts or flavonoids derived from Scutellaria have been scientifically studied for potential anti-cancer activity using in vitro as well as animal models of various cancers, including breast cancer, prostate cancer, ovarian cancer and malignant gliomas. Phase I clinical studies have also been conducted to study the toxicity/efficacy of Scutellaria extract in patients with metastatic breast cancer. This article is a succinct review of pertinent research articles on the anti-tumor efficacy and associated molecular mechanisms of Scutellaria extracts, particularly those containing the flavonoid wogonin. The potential significance of Scutellaria flavonoids as an adjuvant therapy for malignant tumors is discussed.
Export Options
About this article
Cite this article as:
Patel S. Paras, Joshee Nirmal, Rimando M. Agnes and Parajuli Prahlad, Anti-cancer Scopes and Associated Mechanisms of Scutellaria Extract and Flavonoid Wogonin, Current Cancer Therapy Reviews 2013; 9 (1) . https://dx.doi.org/10.2174/1573394711309010004
DOI https://dx.doi.org/10.2174/1573394711309010004 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
Call for Papers in Thematic Issues
Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Challenges and Strategies in Precision Medicine for Non-Small-Cell Lung Cancer
Current Pharmaceutical Design Erythropoietin in Stroke Therapy: Friend or Foe
Current Medicinal Chemistry Therapeutic Targeting of Apoptotic Pathways in Cancer
Current Drug Targets Clinical Applications of the Urokinase Receptor (uPAR) for Cancer Patients
Current Pharmaceutical Design Antibody-Targeted RNase Fusion Proteins (ImmunoRNases) for Cancer Therapy
Current Pharmaceutical Biotechnology Peptides for In Vivo Target-Specific Cancer Imaging
Mini-Reviews in Medicinal Chemistry An Integrative Systems Analysis of High-grade Glioma Cell Lines: TLRs, Wnt, BRCA1, Netrins, STXBP1 and MDH1 Provide Putative Molecular Targets for Therapeutic Intervention
Current Pharmacogenomics and Personalized Medicine Therapeutic Targets for the Management of Peripheral Nerve Injury- Induced Neuropathic Pain
CNS & Neurological Disorders - Drug Targets Development and Clinical Application of Tumor-derived Exosomes in Patients with Cancer
Current Stem Cell Research & Therapy The Neuroprotective Effect of Ginkgo biloba Leaf Extract and its Possible Mechanism
Central Nervous System Agents in Medicinal Chemistry Bcl-2 Family Proteins as Therapeutic Targets
Current Pharmaceutical Design Cancer Preventive Phytochemicals as Speed Breakers in Inflammatory Signaling Involved in Aberrant COX-2 Expression
Current Cancer Drug Targets Curcumin Conjugates and Metallocomplexes as Lead Compounds for Development of Anticancer Agents - A Short Review
Current Bioactive Compounds Histone Variants and Composition in the Developing Brain: Should MeCP2 Care?
Current Topics in Medicinal Chemistry Antibody Engineering for Targeted Therapy of Cancer Recombinant Fv-Immunotoxins
Current Pharmaceutical Biotechnology Urokinase-type Plasminogen Activator (uPA) and its Receptor (uPAR): Development of Antagonists of uPA / uPAR Interaction and their Effects In Vitro and In Vivo
Current Pharmaceutical Design DNA Repair in Normal and Cancer Stem Cells, with Special Reference to the Central Nervous System
Current Medicinal Chemistry ABC Transporters as Potential Targets for Modulation of Drug Resistance
Mini-Reviews in Medicinal Chemistry Proteasome Inhibitors in Cancer Therapy
Current Drug Targets Adenovirus Vectors for Gene Therapy, Vaccination and Cancer Gene Therapy
Current Gene Therapy