Chloroformate Free, Scalable Approach for the Synthesis of Organic Carbamates and Their Alkylation

Author(s): Mukesh P. Shewalkar, Ramakrishna R. Rao, Veerbhadra Reddy, Sunil N. Darandale, Devanand B. Shinde.

Journal Name: Letters in Organic Chemistry

Volume 10 , Issue 1 , 2013

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A convenient method for the synthesis of organic carbamates of 2-aminopyridine without using hazardous chloroformate reagent is developed. This alternate approach for the synthesis of organic carbamates and their alkylation to 2-alkylaminopyridines is more practical and economical to be used on large scale. The amazing behavior of 2- aminopyridine helps in forming organic carbamates unlike 3-aminopyridine and 4-aminopyridine.

Keywords: Alkylation, alkyl aminopyridine, 2-aminopyridine, Boc anhydride, carbamates, prodrugs, maytansine, alkylation, toxic, economical method, chemicals

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Article Details

Year: 2013
Page: [60 - 64]
Pages: 5
DOI: 10.2174/1570178611310010014

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PDF: 52