In many chemical processes, Lewis acids and bases are used to activate reactants simultaneously or sequentially.
The integration of both Lewis base and Lewis acid has great potential to enhance known reactivity and drive the
development of new chemical reactions with high value. In this topic, we disclose herein, the synthesis of 3,4-
Dihydropyrimidin-2(1H)-ones, via one-pot three-component Biginelli condensation, in the presence of Lewis acid/ tertiary
amine as a novel cooperative catalytic system. The high activity and the synergistic effect of this system are well pronounced.
Keywords: Biginelli reaction, cooperative catalysis, dihydropyrimidin-2(1H)-one, DHPMs, DMAP, dual activation, FeCl3,
Lewis acid/ Lewis base system, calcium channel, catalysts
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