Pancreatic Neuroendocrine Tumors: Signal Pathways and Targeted Therapies
L. Peng and R. E. Schwarz
Affiliation: Department of Pathology, UT Southwestern Medical Center, 5909 Harry Hines Boulevard, Dallas, TX 75390-9234, USA.
Pancreatic neuroendocrine tumors (PNETs) are rare but are well understood to cover a broad
spectrum of clinical presentation, tumor biology and prognosis. More than 60% of PNETs are diagnosed at
advanced disease stage and are ineligible for surgical resection. Prior to 2011, streptozocin was the only
approved agent for unresectable advanced PNETs. In recent years, breakthroughs in signal pathway research
have led to the identification of new therapeutic targets and agents directed at the molecular level. In 2011, two
new targeted therapeutic agents, sunitinib and everolimus, were approved by the Food and Drug
Administration (FDA). Sunitinib is an inhibitor of multiple tyrosine kinases, and everolimus is an inhibitor of the
mammalian target of rapamycin (mTOR) pathway. This review discusses the major signaling pathways that are
frequently mutated or deregulated in PNETs, and the implications of molecular alterations for PNET therapy.
Biologic therapy through targeting relevant pathways represents a promising approach in the therapy of
advanced and unresectable PNETs.
Keywords: Pancreatic neuroendocrine tumor, signal pathway, targeted therapies
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