microRNA(miRNA) is a kind of non-coding RNA that has a regulatory function on coding RNA. miRNA can
target the 3’ UTR of mRNA and inhibit its gene expression by either inhibiting its translation or promoting its degradation.
miRNAs are thus considered to be oncogenic or antineoplastic, depending on their downstream target mRNAs.
Besides their clinical application in cancer treatment, diagnosis, and prognosis, miRNA has also recently been reported to
be involved in cancer chemotherapy and chemoprevention. This review focuses on the implication of miRNA in cancer
chemoprevention and cancer control as well as molecular mechanisms underlying those biological effects.
Keywords: Cancer, chemoprevention, expression, gene, microRNA
Rights & PermissionsPrintExport