Title:Inhibitors of HIV-1 Entry
VOLUME: 19 ISSUE: 10
Author(s):Ewa D. Micewicz and Piotr Ruchala
Affiliation:Department of Medicine, Room 37-055 Center for Health Sciences, 10833 LeConte Avenue, Los Angeles, CA 90095.
Keywords:Antivirals, fusion inhibitors, entry inhibitors, peptides, HIV
Abstract:Since the discovery of human immunodeficiency virus (HIV) as a causative agent of acquired immune deficiency syndrome
(AIDS) various strategies were employed to counter its devastating actions. One such concept relies on the prevention of HIV entry into
host’s “competent” cells by means of compounds known as entry inhibitors. HIV entry inhibitors comprise a group of immensely diverse
compounds ranging from proteins/antibodies to small organic molecules and capable of targeting various stages of viral entry. Although
already in clinical use, this approach to HIV therapy is still being investigated to produce new promising antiviral compounds. Here, we
review the latest advances in this area.
