Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay

Author(s): Dejan Godevac, Vele Tesevic, Vlatka Vajs, Slobodan Milosavljevic, Miroslava Stankovic.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 13 , Issue 3 , 2013

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Abstract:

This article summarizes the results of using cytokinesis-block micronucleus (CBMN) assay to evaluate the antioxidant potential of heterocyclic compounds. Most studies were carried out with naturally occurring heterocyclic compounds such as plant polyphenols: flavonoids, xanthones, coumarins, and ellagitannins, or plant derived products (juices, extracts, supplements) rich in bioactive heterocyclic compounds. There are also some studies dealing with synthetic heterocyclic antioxidants. CBMN assay is an in vitro study that has been used to evaluate antioxidant and protective effects of heterocyclic compounds on induced chromosome aberration in human lymphocytes.

Keywords: Antioxidants, CBMN assay, Heterocyclic compounds, Human lymphocytes DNA

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Article Details

VOLUME: 13
ISSUE: 3
Year: 2013
Page: [431 - 438]
Pages: 8
DOI: 10.2174/1389557511313030010
Price: $58

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