The Antioxidant Activity of Coumarins and Flavonoids

Author(s): Guilherme Borges Bubols, Damiana da Rocha Vianna, Alexander Medina-Remon, Gilsane von Poser, Rosa Maria Lamuela-Raventos, Vera Lucia Eifler-Lima, Solange Cristina Garcia.

Journal Name:Mini-Reviews in Medicinal Chemistry

Volume 13 , Issue 3 , 2013

Abstract:

Coumarins and flavonoids are heterocyclic molecules that have been associated with beneficial effects on human health, such as reducing the risk of cancer, diabetes, cardiovascular and brain diseases. These effects are thought to be related to the radical scavenging effect, due to their antioxidant activities, along with other possible mechanisms, such as anti-inflammatory properties and interaction with several enzymes. Over the past two decades, there have been an increasing number of publications on coumarins and flavonoids, which demonstrate the importance of understanding the chemistry behind the antioxidant activities of both natural and synthesized compounds, considering the benefits from their dietary ingestion as well as pharmacological use. This work aims to review the antioxidant effects of coumarin and flavonoid molecules in humans and the structural aspects that contribute to these effects.

Keywords: Antioxidant, coumarins, flavonoids, free radicals, polyphenols, structure-activity relationship

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Article Details

VOLUME: 13
ISSUE: 3
Year: 2013
Page: [318 - 334]
Pages: 17
DOI: 10.2174/1389557511313030002
Price: $58

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