A novel 5-alky-6-(cyclohexylmethyl)-2-((2-hydroxy-2-phenylethyl)thio)-pyrimidin-4(3H)-one derivatives were
synthesized and their ability to inhibit HIV evaluated . The screening results revealed that compounds 2a-g had a favorable
property in inhibiting HIV. The compounds 2b, in particular, showed a special potent anti-HIV activities with EC50
values of 0.003μM and CC50 values of 200 μM. Preliminary structure-activity relationship (SAR) and molecular modeling
analyses of these newly synthesized hydroxylphenethyl-S-DACOs are also discussed.