Recognition that inflammation may contribute to the pathogenesis of various cardiac diseases has naturally led
to the evaluation of the therapeutic potential of a range of anti-inflammatory approaches. Unfortunately, results in most
settings have been disappointing. The majority of novel approaches fail despite promising preclinical data, partly attributable
to off-target effects. The purpose of this review, focused on inflammation following acute myocardial ischemia, is to
give a brief overview of the new insights regarding research on pro-inflammatory signaling cascades that could be targeted
for cardioprotective therapeutic developments.
Keywords: Inflammation, myocardial injury, ischemia-reperfusion
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