Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents)

Bahar Tunctan
Department of Pharmacology
Faculty of Pharmacy
Mersin University
Mersin, 33169
Turkey

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New Insights in Research About Acute Ischemic Myocardial Injury and Inflammation

Author(s): Anne Vincent, Benoit Lattuca, Nolwenn Merlet, Catherine Sportouch-Dukhan, Stephanie Barrere-Lemaire.

Abstract:

Recognition that inflammation may contribute to the pathogenesis of various cardiac diseases has naturally led to the evaluation of the therapeutic potential of a range of anti-inflammatory approaches. Unfortunately, results in most settings have been disappointing. The majority of novel approaches fail despite promising preclinical data, partly attributable to off-target effects. The purpose of this review, focused on inflammation following acute myocardial ischemia, is to give a brief overview of the new insights regarding research on pro-inflammatory signaling cascades that could be targeted for cardioprotective therapeutic developments.

Keywords: Inflammation, myocardial injury, ischemia-reperfusion

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Article Details

VOLUME: 12
ISSUE: 1
Year: 2013
Page: [47 - 54]
Pages: 8
DOI: 10.2174/1871523011312010007