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Current Drug Safety
ISSN (Print): 1574-8863
ISSN (Online): 2212-3911
Epub Full Text Article
DOI: 10.2174/15748863112079990023      Price:  $95

Isolated Unilateral Tongue Oedema: The Adverse Effect of Angiotensin Converting Enzyme Inhibitors

Author(s): Edmund Leung, Marcelino Yazbek Hanna, Nadeem Tehami and James Francombe
Angiotensin converting enzyme inhibitors (ACEI) are widely used to treat benign hypertension. These drugs are generally well tolerated. Serious side effects such as angio-oedema are very rare.

The authors report a 64-year-old Caucasian woman with a history of liver transplant on Mammalian Target Of Rapamycin (mTOR) inhibitor, who attended Emergency department with angio-oedema only on the left side of her tongue. Her airway was patent and she was haemodynamically stable. Trauma was denied. Her physician had 2 days earlier commenced her on Lisinopril for newly diagnosed benign hypertension. Intravenous steroids and anti-histamine were immediately administered. A good response of oedema subsidence was noted.

In general, angio-oedema can present in a spectrum of severity. Precipitating factors are often difficult to pre-determine and avoid. Early recognition of risk factors for and diagnosis of angio-oedema can often be life-saving.

ACE inhibitor, swollen tongue, angioedema
University Hospitals Coventry and Warwickshire, 16 Norton Drive, Warwick, CV34 5FE, UK