Abstract
A controlled drug delivery system which provides stable plasma concentration could be the most appropriate dosage form for the successful delivery of selegiline. The objective of this study was to develop nanospheres of selegiline using gelatin and evaluate in vitro for the feasibility of oral delivery. Nanospheres of selegiline were prepared by spray drying method and evaluated for compatibility, particle size, surface morphology and in vitro drug release. Compatibility studies indicate no interaction between selegiline and gelatin. Moderate production recovery (89.52 ± 3.71%) and high drug content (98.41± 1.22%) were observed for the prepared formulation. Scanning electron microscopy images indicate that the prepared nanospheres possess round external smooth surface with a continuous wall, although they were shriveled. In vitro drug release profile suggests two phase drug release, an initial burst release followed by a slow release over an extended period of time (~10 h). The release kinetics indicates higher regression coefficient values (R2= 0.9641) with Korsmeyer-Peppas fit, suggesting that the release of the drug primarily governed by Fick’s law of diffusion. The in vitro data provided above indicate that the newly developed gelatin nanospheres have the desired characteristics for the controlled delivery of selegiline by oral route, which necessitate further in vivo studies.
Keywords: Selegiline, nanospheres, gelatin, in vitro, release kinetics
Current Nanoscience
Title:Formulation and In Vitro Evaluation of Gelatin Nanospheres for the Oral Delivery of Selegiline
Volume: 9 Issue: 1
Author(s): Bandar E. Al-Dhubiab
Affiliation:
Keywords: Selegiline, nanospheres, gelatin, in vitro, release kinetics
Abstract: A controlled drug delivery system which provides stable plasma concentration could be the most appropriate dosage form for the successful delivery of selegiline. The objective of this study was to develop nanospheres of selegiline using gelatin and evaluate in vitro for the feasibility of oral delivery. Nanospheres of selegiline were prepared by spray drying method and evaluated for compatibility, particle size, surface morphology and in vitro drug release. Compatibility studies indicate no interaction between selegiline and gelatin. Moderate production recovery (89.52 ± 3.71%) and high drug content (98.41± 1.22%) were observed for the prepared formulation. Scanning electron microscopy images indicate that the prepared nanospheres possess round external smooth surface with a continuous wall, although they were shriveled. In vitro drug release profile suggests two phase drug release, an initial burst release followed by a slow release over an extended period of time (~10 h). The release kinetics indicates higher regression coefficient values (R2= 0.9641) with Korsmeyer-Peppas fit, suggesting that the release of the drug primarily governed by Fick’s law of diffusion. The in vitro data provided above indicate that the newly developed gelatin nanospheres have the desired characteristics for the controlled delivery of selegiline by oral route, which necessitate further in vivo studies.
Export Options
About this article
Cite this article as:
E. Al-Dhubiab Bandar, Formulation and In Vitro Evaluation of Gelatin Nanospheres for the Oral Delivery of Selegiline, Current Nanoscience 2013; 9 (1) . https://dx.doi.org/10.2174/1573413711309010006
DOI https://dx.doi.org/10.2174/1573413711309010006 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Thermodynamic and Kinetic Aspects Involved in the Development of Nanocarriers and Drug Delivery Systems Based on Cationic Biopolymers
Current Pharmaceutical Design KiSS1-Induced GPR54 Signaling Inhibits Breast Cancer Cell Migration and Epithelial-Mesenchymal Transition via Protein Kinase D1
Current Molecular Medicine Diverse Roles of GADD45α in Stress Signaling
Current Protein & Peptide Science Targeting Tumor Microenvironment with Silibinin: Promise and Potential for a Translational Cancer Chemopreventive Strategy
Current Cancer Drug Targets Viral Based Gene Therapy for Prostate Cancer
Current Gene Therapy Iontophoretic Mediated Intraarticular Delivery of Deformable Liposomes of Diclofenac Sodium
Current Drug Delivery The Role of Proteomics in Osteoarthritis Pathogenesis Research
Current Drug Targets Hollow Inorganic Nanoparticles as Efficient Carriers for siRNA Delivery: A Comprehensive Review
Current Pharmaceutical Design Therapeutic Transfer of DNA Encoding Adenoviral E1A
Recent Patents on Anti-Cancer Drug Discovery Revisiting the ABCs of Multidrug Resistance in Cancer Chemotherapy
Current Pharmaceutical Biotechnology Withdrawal Notice: Drug Repurposing for Prospective Anti-Cancer Agents Along with the Clinical Status of the Repurposed Drug
Anti-Cancer Agents in Medicinal Chemistry The potential for circulating microRNAs in the diagnosis of myocardial infarction: a novel approach to disease diagnosis and treatment
Current Pharmaceutical Design Cucurbitacins as Inducers of Cell Death and a Rich Source of Potential Anticancer Compounds
Current Pharmaceutical Design Oligonucleotides as Anticancer Agents: From the Benchside to the Clinic and Beyond
Current Pharmaceutical Design Emerging Strategies and Challenges for Controlled Delivery of Taxanes: A Comprehensive Review
Current Drug Metabolism Novel Anticancer Strategy Aimed at Targeting Shelterin Complexes by the Induction of Structural Changes in Telomeric DNA: Hitting two Birds with one Stone
Current Cancer Drug Targets Nanotechnology and Animal Health
Pharmaceutical Nanotechnology Bioinorganic Chemistry: The Study of the Fate of Platinum-Based Antitumour Drugs
Current Chemical Biology Inhibition of TGF- Signaling for the Treatment of Tumor Metastasis and Fibrotic Diseases
Current Signal Transduction Therapy The Function of LncRNA FTX in Several Common Cancers
Current Pharmaceutical Design