Functional Nanoplatforms for Enhancement of Chemotherapeutic Index

Author(s): Jaemoon Yang , Eugene Lee , Minhee Ku , Yong-Min Huh , Jae-Ho Cheong .

Journal Name: Anti-Cancer Agents in Medicinal Chemistry

Volume 13 , Issue 2 , 2013

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Recently, the advancement of nanotechnology has had a significant impact on clinical therapeutics. Advances in biocompatible drug carriers using organic/inorganic nanoparticles have enabled safer and more efficient delivery of anti-cancer agents. In particular, nanoparticles designed and fabricated by sophisticated processes can (as drug carriers) deliver precise doses of multiple anti-cancer agents to target cancer cells, improving therapeutic efficacy and minimizing side effects. In addition, a comprehensive understanding of cancer biology, chemo-resistance, cancer relapse, and metastasis is essential for successful development of combination therapy using nanoparticles. In this review, we discuss the species of functional nanoparticles for delivery of anti-cancer agents and their potential to improve chemotherapeutic indices via combination therapy. We also discuss novel therapeutic strategies using functional nanoparticles developed through multidisciplinary collaboration for combination chemotherapy.

Keywords: Anti-cancer agents, Cancer, Combination chemotherapy, Nanoparticle, Synergistic effect

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Article Details

Year: 2013
Page: [212 - 221]
Pages: 10
DOI: 10.2174/1871520611313020005
Price: $58

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PDF: 43