Alzheimer’s disease (AD) is one of the major neurodegenerative diseases affecting almost 28 million people
around the globe. It consistently remains one of the major health concerns of present world. Due to the clinical limitations
like severe side effects of some synthesized drugs, alternative forms of treatments are gaining global acceptance in the
treatment of AD. Neuroprotective compounds of natural origin and their synthetic derivatives exhibit promising results
with minimal side effects and some of them are in their different phases of clinical trials. Alkaloids and their synthetic
derivatives form one of the groups which have been used in treatment of neurodegenerative diseases like AD. We have
further grouped these alkaloids into different sub groups like Indoles, piperdine and isoquinolines. Polyphenols form
another important class of natural compounds used in AD management.
Keywords: Alkaloids, polyphenols, Alzheimer’s disease, neuroprotective function, Indoles, piperdine, isoquinolines, dementia, Physostigma venenosum, Rutaecarpine.
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