The Role of Cysteine Proteinases and their Inhibitors in the Host-Pathogen Cross Talk

Author(s): Natasa Kopitar-Jerala .

Journal Name: Current Protein & Peptide Science

Volume 13 , Issue 8 , 2012

Become EABM
Become Reviewer

Abstract:

Proteinases and their inhibitors play essential functional roles in basic biological processes in both hosts and pathogens. Endo/lysosomal cathepsins participate in immune response in pathogen recognition and elimination. They are essential for both antigen processing and presentation (host adaptive immune response) and activation of endosomal Toll like receptors (innate immune response). Pathogens can produce proteases and also natural inhibitors to subvert the host immune response. Several pathogens are sensed through the intracellular pathogen recognition receptors, but only some of them use the host proteolytic system to escape into the cytosol. In this review, I provide an update on the most recent developments regarding the role of proteinases and their inhibitors in the initiation and regulation of immune responses.

Keywords: Bacteria, immune response, protease/cysteine proteinase, proteinase inhibitor, virus, Cysteine Cathepsins, Endogenous Protein Inhibitors, Dendritic Cells, CMKLR1, C-terminus

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 13
ISSUE: 8
Year: 2012
Page: [767 - 775]
Pages: 9
DOI: 10.2174/1389203711213080006

Article Metrics

PDF: 12