Bacterial Cell Division Regulation by Ser/Thr Kinases: A Structural Perspective

Author(s): Alessia Ruggiero , Paola De Simone , Giovanni Smaldone , Flavia Squeglia , Rita Berisio .

Journal Name: Current Protein & Peptide Science

Volume 13 , Issue 8 , 2012

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Abstract:

Recent genetic, biochemical and structural studies have established that eukaryotic-like Ser/Thr protein-kinases are critical mediators of developmental changes and host pathogen interactions in bacteria. Although with lower abundance compared to their homologues from eukaryotes, Ser/Thr protein-kinases are widespread in gram-positive bacteria. These data underline a key role of reversible Ser/Thr phosphorylation in bacterial physiology and virulence. Numerous studies have revealed how phosphorylation/dephosphorylation of Ser/Thr protein-kinases governs cell division and cell wall biosynthesis and that Ser/Thr protein kinases are responsible for distinct phenotypes, dependent on different environmental signals. In this review we discuss the current understandings of Ser/Thr protein-kinases functional processes based on structural data.

Keywords: Cell division, structure, phosphorylation, peptidoglycan, Bacterial Cell Division, STPKs, KINASE DOMAIN, PASTA, MviN, EXTRACELLULAR REGION

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Article Details

VOLUME: 13
ISSUE: 8
Year: 2012
Page: [756 - 766]
Pages: 11
DOI: 10.2174/1389203711213080005

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