Learning from Bacteriophages - Advantages and Limitations of Phage and Phage-Encoded Protein Applications

Author(s): Zuzanna Drulis-Kawa , Grazyna Majkowska-Skrobek , Barbara Maciejewska , Anne-Sophie Delattre , Rob Lavigne .

Journal Name: Current Protein & Peptide Science

Volume 13 , Issue 8 , 2012

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Abstract:

The emergence of bacteria resistance to most of the currently available antibiotics has become a critical therapeutic problem. The bacteria causing both hospital and community-acquired infections are most often multidrug resistant. In view of the alarming level of antibiotic resistance between bacterial species and difficulties with treatment, alternative or supportive antibacterial cure has to be developed. The presented review focuses on the major characteristics of bacteriophages and phage-encoded proteins affecting their usefulness as antimicrobial agents. We discuss several issues such as mode of action, pharmacodynamics, pharmacokinetics, resistance and manufacturing aspects of bacteriophages and phage-encoded proteins application.

Keywords: antibiotics, bacterial multidrug resistance, bacteriophage therapy, phage-encoded proteins application, Bacteriophages, ANTIMICROBIAL DRUG RESISTANCE, Bacterial Anti-Phage Resistance, PHAGE-ENCODED PROTEINS, EPS- Degrading Phage Enzymes, Bacterial Protein Synthesis

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Article Details

VOLUME: 13
ISSUE: 8
Year: 2012
Page: [699 - 722]
Pages: 24
DOI: 10.2174/1389203711213080002

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