Lung cancer (LC) is a highly prevalent malignancy mainly caused by long-term exposure to tobacco smoke,
although other substances in the workplace can also cause LC. This paper reviews carcinogens in the workplace linked
with occupational LC, including asbestos, radon, silica, nickel, beryllium, chromium and polycyclic aromatic
In LC of occupational origin, diagnosis can be difficult due to co-exposure to various carcinogens. The present review is
intended to provide additional information that may help in the diagnostic approach and discusses controversial issues on
certain substances like silica, beryllium or PAH as etiological factors of LC. Finally, occupational LC preventive
measures are discussed.