Abstract
Meta-analyses are useful to summarize the exponential amount of inconsistent and conflicting neuroimaging data. However, they are usually separately conducted for each different neuroimaging modality, preventing the multimodal integration of different imaging findings in a given neuropsychiatric disorder. Here, we describe an innovative method to meta-analytically combine the results of different imaging modalities, such as structural and functional paradigms. The method accounts for the presence of noise in the estimation of the p-values, and can be easily applied to any meta-analytical software. We hope that with this advanced imaging tool, researchers will be able to provide more complete multimodal pictures of the brain regions affected in different neuropsychiatric disorders.
Keywords: Functional magnetic resonance imaging, voxel based analysis, gray matter, meta-analysis, multi-modality, neuroimaging, psychosis
Current Medicinal Chemistry
Title:A General Approach for Combining Voxel-Based Meta-Analyses Conducted in Different Neuroimaging Modalities
Volume: 20 Issue: 3
Author(s): J. Radua, M. Romeo, D. Mataix-Cols and P. Fusar-Poli
Affiliation:
Keywords: Functional magnetic resonance imaging, voxel based analysis, gray matter, meta-analysis, multi-modality, neuroimaging, psychosis
Abstract: Meta-analyses are useful to summarize the exponential amount of inconsistent and conflicting neuroimaging data. However, they are usually separately conducted for each different neuroimaging modality, preventing the multimodal integration of different imaging findings in a given neuropsychiatric disorder. Here, we describe an innovative method to meta-analytically combine the results of different imaging modalities, such as structural and functional paradigms. The method accounts for the presence of noise in the estimation of the p-values, and can be easily applied to any meta-analytical software. We hope that with this advanced imaging tool, researchers will be able to provide more complete multimodal pictures of the brain regions affected in different neuropsychiatric disorders.
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Cite this article as:
Radua J., Romeo M., Mataix-Cols D. and Fusar-Poli P., A General Approach for Combining Voxel-Based Meta-Analyses Conducted in Different Neuroimaging Modalities, Current Medicinal Chemistry 2013; 20 (3) . https://dx.doi.org/10.2174/0929867311320030017
DOI https://dx.doi.org/10.2174/0929867311320030017 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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