Serotonin Receptors of Type 6 (5-HT6): From Neuroscience to Clinical Pharmacology

Author(s): Donatella Marazziti, Stefano Baroni, Franco Borsini, Michela Picchetti, Elena Vatteroni, Valentina Falaschi, Mario Catena-Dell’Osso.

Journal Name: Current Medicinal Chemistry

Volume 20 , Issue 3 , 2013

Abstract:

The serotonin (5-HT) receptors of type 6 (5-HT6) are quite different from all other 5-HT receptors, as they include a short third cytoplasmatic loop and a long C-terminal tail, and one intron located in the middle of the third cytoplasmatic loop.

A lot of controversies still exist regarding their binding affinity, effects of 5-HT6 ligands on brain catecholamines, behavioral syndromes regulated by them, and brain distribution.

In spite of the lack of information on metabolic pattern of the various compounds, some of 5-HT6 receptor ligands entered the clinical development as potential anti-dementia, antipsychotic, antidepressant and anti-obese drugs.

The present paper is a comprehensive review on the state of art of the 5-HT6 receptors, while highlighting the potential clinical applications of 5-HT6 receptor agonists/antagonists.

Keywords: Serotonin, serotonin receptors, serotonin receptors of type 6, agonists, antagonists, neurochemistry, distribution, clinical pharmacology

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Article Details

VOLUME: 20
ISSUE: 3
Year: 2013
Page: [371 - 377]
Pages: 7
DOI: 10.2174/0929867311320030008

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