Facilitative Effect of Serotonin1A Receptor Agonists on Cognition in Patients with Schizophrenia

Author(s): T. Sumiyoshi, Y. Higuchi.

Journal Name: Current Medicinal Chemistry

Volume 20 , Issue 3 , 2013

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Disturbances of cognitive function are considered to largely affect the outcome in patients with schizophrenia. There is much attention to the role of psychotropic compounds acting on serotonin (5-HT) receptors in ameliorating cognitive deficits of the disease. Among the 5-HT receptor subtypes, the 5-HT1A receptor is attracting particular interests as a potential target for enhancing cognition, based on preclinical and clinical evidence. The neural network underlying the ability of 5-HT1A agonists to treat cognitive impairments of schizophrenia likely includes dopamine, glutamate, and gamma-aminobutyric acid neurons. Recent advances of electrophysiological measures, such as event-related potentials, have provided insights into facilitative effects on cognition of some atypical antipsychotic drugs or related compounds acting directly or indirectly on 5-HT1A receptors. These considerations are expected to promote the development of novel therapeutics for the betterment of functional outcome in people suffering from schizophrenia.

Keywords: Cognitive function, Serotonin, 5-HT1A, prefrontal cortex, glutamate, GABA, electrophysiology, event-related potentials

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Article Details

Year: 2013
Page: [357 - 362]
Pages: 6
DOI: 10.2174/0929867311320030006
Price: $58

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