Rupestonic acid (isolated from the Chinese traditional medicine Artemisia rupestris L.) is a sesquiterpene with
multifunctional groups and possess higher activity against influenza virus B. In order to improve the biological activity of
rupestonic acid, many derivatives have been synthesized and their anti-influenza activity was screened. This review
describes the rupestonic acid derivatives and their anti-influenza activity studied by our researching group.
Keywords: Rupestonic acid derivatives, anti-influenza virus, structure-activity relationship
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