Antioxidant Hybrid Compounds: A Promising Therapeutic Intervention in Oxidative Stress Induced Diseases

Author(s): Navin Tailor, Manu Sharma.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 13 , Issue 2 , 2013

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Abstract:

Reactive oxygen species/nitrogen species (ROS/RNS) are major causative agents of oxidative stress related diseases such as neurodegenerative, cancer, cardiovascular, and inflammation via intracellular signal transduction pathways. Synthetic modification of antioxidants and development of hybrid compounds by conjugation or integration of two or more moiety opened a new era in development of antioxidant based therapeutics. In this review, our attention is focused on structural, chemical and biochemical feature of free radicals, description of mechanistic modulation in signaling pathways by antioxidants and establishment of relationship between structural and biological accepts of antioxidant hybrid systems (1,2-dithiolone, ,α-βunsaturated carbonyl, cinnamate based hybrids and miscellaneous hybrids).

Keywords: Antioxidant hybrid compound, reactive oxygen species, structure-activity relationship

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Article Details

VOLUME: 13
ISSUE: 2
Year: 2013
Page: [280 - 297]
Pages: 18
DOI: 10.2174/1389557511313020010
Price: $58

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