Polyglandular Autoimmune Syndromes

Author(s): Khaled El Baba , Mira Zantout , Sami T. Azar .

Journal Name: Current Immunology Reviews

Volume 8 , Issue 4 , 2012

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Abstract:

Polyglandular Autoimmune Syndromes (PAS) form different clusters of autoimmune disorders characterized by the coexistence of at least two glandular autoimmune mediated diseases [1]. They are generally classified into three types: a very rare juvenile type 1(PAS I) and a relatively common adult type with (PAS II) or without adrenal failure (PAS III) [2, 3]. PAS I, also known as autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), is associated with candidiasis, hypoparathyroidism, and adrenal failure. PAS II is associated with adrenal failure, thyroid diseases and type 1 diabetes mellitus. In this review we will shed light on both types of PAS including their clinical picture and ways of management.

Keywords: Addison’s disease, AIRE gene mutation, candidiasis, chronic hypoparathyroidism, Hashimoto's thyroiditis, hyperthyroidism, polyglandular autoimmune syndromes, type I diabetes mellitus

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Article Details

VOLUME: 8
ISSUE: 4
Year: 2012
Page: [263 - 267]
Pages: 5
DOI: 10.2174/1573395511208040001
Price: $58

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