The Effects of Direct Renin Inhibitor, Aliskiren, on Arterial Hypertension, Chronic Kidney Disease and Cardiovascular Disease: Optimal Pharmacotherapy

Author(s): Yoshiyuki Morishita, Eiji Kusano.

Journal Name: Cardiovascular & Hematological Agents in Medicinal Chemistry

Volume 11 , Issue 1 , 2013

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Abstract:

The renin-angiotensin-aldosterone system (RAAS) plays pivotal roles in the pathogenesis of progression of arterial hypertension, chronic kidney disease (CKD) and cardiovascular disease (CVD). Previous studies suggested that a direct renin inhibitor, aliskiren, may be effective for blood pressure lowering, renoprotection and cardiovascular protection. This review focuses on the effects of aliskiren for arterial hypertension, CKD and CVD.

Keywords: Aliskiren, angiotensin receptor blockers, angiotensin-converting enzyme inhibitors, arterial hypertension, cardiovascular disease, chronic kidney disease, clinical trials, combination therapy, direct renin inhibitor, reni-angiotensinaldosterone system

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Article Details

VOLUME: 11
ISSUE: 1
Year: 2013
Page: [77 - 82]
Pages: 6
DOI: 10.2174/1871525711311010012

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