The renin-angiotensin-aldosterone system (RAAS) plays pivotal roles in the pathogenesis of progression of
arterial hypertension, chronic kidney disease (CKD) and cardiovascular disease (CVD). Previous studies suggested that a
direct renin inhibitor, aliskiren, may be effective for blood pressure lowering, renoprotection and cardiovascular
protection. This review focuses on the effects of aliskiren for arterial hypertension, CKD and CVD.
Keywords: Aliskiren, angiotensin receptor blockers, angiotensin-converting enzyme inhibitors, arterial hypertension,
cardiovascular disease, chronic kidney disease, clinical trials, combination therapy, direct renin inhibitor, reni-angiotensinaldosterone system
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